The victory snapped a five-game losing streak for the Moose, while ending the Wolves' seven-game points streak (5-0-0-2).
Lee Goren recorded two goals and an assist and Jason Jaffray added three assists for Manitoba. Prestin Ryan also scored for the Moose.
Colin Stuart, Mark Popovic and Jon Awe scored for the Wolves.
Drew MacIntyre made 29 saves for Manitoba while Michael Garnett stopped 24 shots for Chicago.