Ray Whitney scored twice and Erik Cole had a goal and two assists for Carolina (7-6-2), while goalie Cam Ward stopped 24 shots.
Daniel Alfredsson and Denis Hamel scored for the Senators (5-7-0). Martin Gerber faced 40 shots in his first game against his former teammates.
After dealing with trade rumours and much criticism this past week, Alfredsson finally managed to pick up a goal on his very first shift. The Senators captain beat Ward high glove side to the delight of the 19,648 on hand.
Gerber looked solid early, but one of his best saves of the night came in the opening minutes of the second as he stopped Eric Staal on a breakaway.
The Senators made it 2-0 three minutes into the third period when Hamel beat a sliding Ward through the legs.
Carolina got on the board with a power-play goal late in the second as Cole was able to squeeze the puck pass Gerber at the side of the net. With an assist on the play, Rod Brind'Amour picked up his 1,000th career point. Whitney tied the game 58 seconds into the third period as he beat Gerber far-side.
The Senators failed to capitalize on a 71-second two-man advantage despite a number of good chances. The Senators were 0-for-7 with the man advantage.
The Hurricanes were much more opportunistic as they made the most of back-to-back power plays. They were 2-for-6 with the extra man.
Carolina took the first lead of the game on a power-play goal by Whitney midway through the first period.
Notes: Ottawa D Wade Redden missed his third straight game with a groin injury. C Alexei Kaigorodov was suspended for failing to report to the AHL's Binghamton Senators Saturday. G Martin Gerber received his Stanley Cup ring from Carolina GM Jim Rutherford prior to the game. Mike Fisher wore an "A" in Redden's absence ... The Hurricanes were without D Tim Gleason (shoulder), D Frantisek Kaberle (shoulder), C Keith Aucoin (foot), F Trevor Letowski (concussion) and F Cory Stillman (shoulder).