Chris Pronger had two goals and an assist for Anaheim, which is chasing its first division title since entering the league in 1993 and the President's Trophy for the most regular-season points.
Ryan Getzlaf and Francois Beauchemin each added a goal and an assist.
The Ducks, who won 3-1 in Chicago on Wednesday, moved six points ahead of Dallas atop the Pacific Division. They won their 46th game and now have 104 points, extending their franchise records.
Aaron Johnson and Sergei Fedorov scored for Columbus, which had a 2-1 lead early in the third period but had its four-game win streak snapped.