Sedin's goal at 3:02 of overtime spoiled a comeback attempt from the Carolina Hurricanes and gave the Canucks a 4-3 win.
The Canucks looked to have the game locked up with 3-0 lead early in the third period, then saw the Hurricanes storm back to tie match with just under three minutes remaining.
"When you're up 3-0 you should hold onto the lead," said Sedin, who ended a wild night when he tapped a cross-ice pass from his brother Henrik past Carolina goaltender Cam Ward.
"We can't think too much about that. We got the two points and that was the most important thing. The puck movement was good. It was a good team game."
Vancouver scored its fourth power-play goal of the game after the Hurricanes Scott Walker was sent off for delay of game for shooting a puck over the glass. Walker slammed his stick against the glass after the call.
The Canucks are now 5-0 in overtime. Daniel Sedin has two overtime goals.
Carolina coach Peter Laviolette didn't want to comment on Walker's penalty.
"What difference does it make?" he said. "It's a rule. It doesn't matter what I think. You win by it, you lose by it, you live by it.
"Scott is the heart-and-soul guy of this team. We will persevere together."
Still, it was a frustrating loss for the Hurricanes, who battled back only to fall one goal short.
"Any time you lose in overtime, on a delay of game penalty, it's tough, especially when we worked to come back," said Eric Staal, who missed on a second-period penalty shot.
"I thought we fought hard all game but the bottom line is that we didn't win and that's what we're looking to do."
Jan Bulis, who snapped a 13-game goal drought, Marc Chouinard and Yannick Tremblay scored for the Canucks. Brendan Morrison also had three assists for Vancouver, who crawl back to .500 with a 14-14-1 record.
Erik Cole had a power-play goal and two assists for the defending Stanley Cup champion Hurricanes, who lost their third consecutive game on a swing through the Northwest Division. Craig Adams and Mike Commodore also scored for the Hurricanes, who dropped to 15-12-4.
Canuck coach Alain Vigneault looked subdued after the win.
"If that's excitement then I'm not high on that type of excitement," said Vigneault. "At 3-0 we should have been able to shut it down there.
"They are a really strong team. We made a couple of mistakes and took a couple of penalties we shouldn't of. They jumped on it and tied it up."
The Hurricanes outshot the Canucks 39-31 but struggled on the power play, going 1-7.
Vancouver looked to have the game in the bag when Tremblay, playing his first game with the Canucks since being called up from the American Hockey League's Manitoba Moose for injured defenceman Sami Salo, made it 3-0 at 5:17 of the third.
Adams got the Hurricanes on the scoreboard just 17 second later. Cole made it 3-2 on a power play at 15:42, then Commodore tied the game at 17:14.
Chouinard's goal was his first of the season and came in his 20th game as a Canuck since signing as a free agent.
"It was a way of breaking the ice," said Chouinard, who was playing on the power play for the first time this season. "It took a little more time than I expected."
The Hurricanes started the game with a gale-force effort, forcing goaltender Roberto Luongo to be sharp. The big goalie set the tone early by first stopping a Cole shot, then getting into position to block Adams' swipe at the rebound. He also gloved a laser blast from Justin Williams.
Notes: The Canucks lost forward Tommi Santala with a knee injury in the first period. He's expected to miss three weeks to a month. ...Vancouver will recall forward Lee Goren from Manitoba for Saturday night's game in Calgary. ... The Hurricanes have six players who have scored 10 or more goals while Markus Naslund is the only Canuck to reach that mark.