It was the fifth straight victory for the Coyotes, who also got goals from Shane Doan, who scored twice, Ladislav Nagy and Owen Nolan. Marian Hossa scored twice and Ilya Kovalchuk and Jonathan Sim once each for the Thrashers.
Hossa scored his first goal since Dec. 19 at 13:44 of the opening period, and Kovalchuk made it 2-0 at 15:45.
In the second period, Doan beat Hedberg at 1:15 and Hossa got his 26th at 3:01.
In the third, Sim put the Thrashers up 4-1 at 1:28, but the Coyotes rallied on goals by Nagy at 2:14, by Doan on a power play at 10:40 and by Nolan at 13:21 before Perreault ended it with a backhander.