The Thrashers moved into a tie with Tampa Bay for first place in the Southeast Division. Carolina, which had won the three previous games with the Thrashers in Atlanta this season, are five points behind the division leaders and clinging to the final playoff spot in the Eastern Conference.
Rod Brind'Amour scored in the closing seconds of the first period for the defending Stanley Cup champion Hurricanes.
The Thrashers have won three straight games since acquiring Keith Tkachuk and Alexei Zhitnik just before the trade deadline. Tkachuk got his first point with Atlanta on Ilya Kovalchuk's power-play goal that broke a tie in the second period.
Hossa had a chance for three goals, but missed an open net in the final seconds after Carolina pulled goalie John Grahame.
Hossa's second goal came on an assist from Bobby Holik for Holik's 700th career point.