Skrastins, who broke Tim Horton's mark of 486 on Feb. 8 against Atlanta, sustained the injury during Saturday night's 5-4 shootout loss to the Los Angeles Kings. Horton set the mark for defencemen while playing for Toronto from 1961-68.
The 32-year-old defenceman hadn't missed a game since Feb. 18, 2000, when he was with the Nashville Predators, and his run started three days later against Dallas. His streak was not easy to achieve, considering he was second in the NHL in blocked shots last season (207) and third this season (174).
Skrastins played in the final 23 games of the 1999-00 season, all 82 in each of the next five campaigns and the first 62 Avalanche contests in 2006-07.
Vancouver's Brendan Morrison now holds the league's longest current streak for any position at 492 games. The longest overall playing streak in NHL history is 964 by Doug Jarvis.