Sami Kapanen scored the first of his two goals during Philadelphia's first-period barrage, which drove Giguere to the bench with 3:34 left in the period. Giguere entered the game 10-0-4 with a 1.98 goals-against average and had allowed only four goals on 77 shots over his previous four games.
Mike Knuble, Simon Gagne and Geoff Sanderson each had a power-play goal and an assist for the Flyers, who came in with an NHL-worst 3-12-2 record. But they handed the Western Conference leaders their first regulation loss at home despite getting outshot 41-16.
Alexandre Picard had a power-play goal in the third, one of three by the Flyers with the man advantage.
The Flyers have had three other six-game losing streaks, most recently Jan. 25-Feb. 5, 1994. They are 3-6-1 since John Stevens replaced Ken Hitchcock as coach on Oct. 22.
Andy McDonald and Dustin Penner had power-play goals for the Ducks, who have lost two of three since setting an NHL record with points in their first 16 games. Chris Kunitz and Samuel Pahlsson also scored for Anaheim against Robert Esche, who made 37 saves.