Colorado Avalanche Andrew Brunette, left, tries to score against Edmonton Oilers goalie Dwayne Roloson during second period NHL action in Edmonton, Alta., Wednesday. (CP/Jason Scott)
Joe Sakic, John-Michael Liles and Brett Clark also scored for Colorado while Patrick Thoresen had the only goal for Edmonton.
With the victory the Avalanche (38-29-6) are now 9-0-1 in their last 10 games and are once again just four points back of the Calgary Flames for the eighth and final playoff spot in the Western Conference.
The Oilers (30-37-7) have yet to record a win in their 11 games since trading forward Ryan Smyth to the New York Islanders, and are nearing the team-record 14 game winless streak from the 1993-94 season.
The Avalanche buried Edmonton quickly in this one, scoring just 1:29 in. The Oilers couldn't clear a puck that was bouncing around in the crease in front of netminder Dwayne Roloson and Laperriere was there to swat it in.
Colorado went up 2-0 less than three minutes later as Andrew Brunette outmuscled Raffi Torres behind the Edmonton net and sent a backhander out front to Sakic who one-timed his 31st of the season past Roloson.
Colorado kept coming in waves to start the second as well and got another early goal on the injury-riddled Oilers. Tyler Arnason found Laperriere with a no-look backhand pass from behind the net and the Avs assistant captain scored on a wrist shot for his second of the night and a 3-0 lead.
The Avalanche chased Roloson from the Edmonton net with just over five minutes left in the second as Liles scored on a power-play point shot.
Jussi Markkanen came on in relief between the pipes for the Oilers. He didn't fare much better as the Avalanche went ahead 5-0 a minute and a half later when Clark converted on a 2-on-1 pass from Brunette.
Edmonton was finally able to bust Peter Budaj's shutout bid five minutes into the third as Fernando Pisani picked off a pass while short handed and saw the rebound on his shot squirt out to Thoresen who scored his first goal since Oct. 17.
The Oilers and Avalanche will both remain in Edmonton for a rematch on Friday.
Notes: With Calgary's 2-1 victory over Detroit on Tuesday the Oilers were officially eliminated from the playoffs, one year removed from playing in Game Seven of the Stanley Cup Final. With nine games to go, it marked the earliest Edmonton has ever been knocked out of contention. . . . With the Oilers out, veteran defenceman Steve Staios has opted to have surgery on his left knee rather than trying to come back this season. Staios was one of 10 injured players missing from the Edmonton lineup. . . . Budaj has played in all but four of the Avalanche's last 33 games dating back to December 27. . . . The Avalanche haven't missed the playoffs since moving to Colorado in 1995. . . . Colorado's Peter Stastny was held pointless, ending his NHL rookie record road scoring streak at 15 consecutive games.